ScourGuard 4KC cattle vaccine is administered to aid in the prevention of rotavirus, coronavirus, Clostridium perfringens Type C, and K99 E. coli. Vaccinate pregnant cattle to provide scour protection to calves through the colostrum. Give 2 ml intramuscularly, six to nine weeks before calving. Repeat three to six weeks before calving. An annual booster of ScourGuard is recommended about three to six weeks before subsequent calvings. ScourGuard is a killed vaccine.